18 Oct Enineering Power – Bulletin of the Croatian Academy of Engineering – Vol. 13(1)
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Croatian Academy of Engineering (HATZ) 2018This issue is dedicated to the scientific work in the field of biomechanical engineering in the Laboratory for numerical Mechanics at the Faculty of Mechanical engineering and Naval Arhitecture, University of Zagreb. Our work concerns modeling of soft tissue behavior, particularly abdominal aortic aneurysms (AAAs) development. We addressed the problem of intraluminal thrombus enlargement within abdominal aortic aneurysm. Our mail goal was to develop a theoretical and computational biochemomechanical model of evolving properties of ILT incorporated into an initially healthy artery.We showed that thrombus-laden lesions can either arrest or rupture depending on the biochemical (e.g., concentration of elastases) and biomechanical (stiffness of fibrin) properties of the ILT. The herein presented results are the results of fruitful cooperation with Jay D Humphrey's group from Yale university, USA, Gerhard Holzapfel's group from TU Graz, austria, Seungik Baek from Michigan state University, USA and Ivo Lovričević, Medical School, University of Zagreb. The scientific work in our group was supported by grants from the Croatian Science Foundation project IP-2014-09-7382 and Installation Grant to I. Karšaj.